We present a direct discretization of the electronic Schrödinger equation. It is based on one-dimensional Meyer wavelets from which we build an anisotropic multiresolution analysis for general particle spaces by a tensor product construction. We restrict these spaces to the case of antisymmetric functions. To obtain ﬁnite-dimensional subspaces we ﬁrst discuss semidiscretization with respect to the scale parameter by means of sparse grids which relies on mixed regularity and decay properties of the electronic wave functions. We then propose different techniques for a discretization with respect to the position parameter. Furthermore we present the results of our numerical experiments using this new generalized sparse grid methods for Schrödinger’s equation.